The study was done on women who were asked to paint their nails and then were subjected to testing for the chemical compound. The appearance of TPHP was said to be higher after using the polish and the results were said to be "alarming." The hypothesis for the way TPHP entered the body is that it might be entering your cuticles or through the nail bed itself facilitated by other chemicals in nail polish that cause nails to be more permeable.
According to the study, "TPHP causes endocrine disruption, meaning that it interferes with normal hormone functioning. In animals studies, it has caused reproductive and development irregularities." While watching the news last night, they said that the effects on reproductive functions might be more pronounced in young children and teenagers, where as, it was said to be linked to weight gain in adult women. But all this might not be reason enough for me to throw out all my nail polishes since this study was not done on humans for a significant period of time and only some polishes contain the substance.